- High school student Homura Suzuko has returned to Ikebukuro, the town where she grew up.
"We're friends forever!" She treasures her memories of her old friend from when she was little, Morikawa Chinatsu, and she's excited at the prospect of meeting her again.
But when she gets to school, she finds she has trouble fitting in with the rest of the class.
One day, she decides that if she learns to play the card game WIXOSS, she might be able to make some friends. She stops at a card shop on her way home and buys a deck set. When she takes the set home and opens it, the girl on one of the cards begins to move, and speak.